Protective effect of dehydroepiandrosterone against aflatoxin B1-and 7,12-dimethylbenz(a)anthracene-induced cytotoxicity and transformation in cultured cells.
نویسندگان
چکیده
Dehydroepiandrosterone, an adrenal steroid that has been reported to be produced in subnormal amounts and found in lower plasma concentrations in women with benign and malignant breast tumors, protects cultured rat liver epithelial-like cells against aflatoxin B1-induced cytotoxicity and protects hamster embryonic fibroblasts against aflatoxin B1- and 7,12-dimethylbenz(a)anthracene-induced transformation. Related androgenic steroids show significantly less protective effect. Dehydroepiandrosterone also inhibits the rate of conversion of [3H]-7,12-dimethylbenz(a)anthracene to water-soluble metabolites by rat liver epithelial-like cells, suggesting that the steroid probably exerts its protective effect by inhibiting carcinogen activation.
منابع مشابه
Influence of "Feeder Cells" and Inducers and Inhibitors of Microsomal Mixed-Function Oxidases on Hydrocarbon-induced Malignant Transformation of Cells Derived from C3H Mouse Prostate1
prostate (which metabolized hydrocarbons poorly) increased the cytotoxicity of 3-methylcholanthrene and 7,12-dimethylbenz[a] anthracene but did not affect the cytotoxicity of the K-region epoxide of 3-methylcholanthrene. The yield of malignant transformation in vitro produced by 3-methyl cholanthrene was significantly increased by the addition of "feeder cells." The yield induced by 7,12-dimeth...
متن کاملInfluence of "feeder cells" and inducers and inhibition of microsomal mixed-function oxidases on hydrocarbon-induced malignant transformation of cells derived from C3H mouse prostate.
prostate (which metabolized hydrocarbons poorly) increased the cytotoxicity of 3-methylcholanthrene and 7,12-dimethylbenz[a] anthracene but did not affect the cytotoxicity of the K-region epoxide of 3-methylcholanthrene. The yield of malignant transformation in vitro produced by 3-methyl cholanthrene was significantly increased by the addition of "feeder cells." The yield induced by 7,12-dimeth...
متن کاملThe coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism.
The diterpenes cafestol and kahweol (C&K) have been identified in animal models as two potentially chemoprotective agents present in green and roasted coffee beans. It has been postulated that these compounds may act as blocking agents by producing a co-ordinated modulation of multiple enzymes involved in carcinogen detoxification. In this study, we investigated the effects of C&K against the c...
متن کاملScreening seven Iranian medicinal plants for protective effects against β-Amyloid-induced cytotoxicity in cultured cerebellar granule neurons
Background and objectives: Alzheimer's disease (AD) as a neurodegenerative disorder is the most common form of dementia in the elderly. According to the amyloid hypothesis, accumulation of amyloid beta (Aβ) plaques, which are mostly constituted of Aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. Thus, modulation of Aβ toxicity is the hopef...
متن کاملMalignant transformation of a cloned, nontumorigenic mouse epidermal keratinocyte cell line, MSK-C3H-NU, by 7,12-dimethylbenz(a)anthracene.
MSK-C3H-NU, a cloned mouse epidermal keratinocyte cell line, was established from the epidermis of C3H/HeN mammary tumor virus-positive nude mice. Although it has lost its diploid chromosome number, the cell line is nontumorigenic, has been stable during serial subcultivations for over 2 years, and has retained some differentiated biological characteristics of normal keratinocytes. MSK-C3H-NU c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 35 9 شماره
صفحات -
تاریخ انتشار 1975